CITY

The CITY project – Cardiovascular Immunopathology and Therapeutics for Youth – tackles a challenge that is still far too underrecognized: heart failure in young adults. Although this disease is often associated with aging, it is affecting an increasing number of people under 50, both in France and internationally. Yet studies and medical recommendations remain largely focused on older patients, leaving these young patients without appropriate answers tailored to their needs.

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To meet this challenge, CITY brings together a unique interdisciplinary consortium, bringing together physicians, cardiovascular biology researchers, immunology specialists, and experts in the humanities and social sciences. Together, they aim to decipher the immuno-inflammatory mechanisms that worsen the disease, identify new biomarkers for earlier diagnosis, and develop innovative therapies targeting the immune system.

CITY’s originality also lies in its integration of clinical linguistics, which explores how language and representations influence young patients’ relationship to their illness and their medical care. This innovative approach helps support patients and their families by overcoming barriers linked to the announcement of the diagnosis and encouraging better adherence to treatment.

CITY builds on the strength of more than twenty research teams from Université Paris Cité, Inserm, and Institut Pasteur:

  • LVTS (Inserm U1148) : Cardiovascular Immunobiology (A. Nicoletti / G. Caligiuri), Cardiovascular Genetics (C. Le GOFF /M. VARRET), Cardiovascular Imaging (F. Rouzet), Recherche clinique cardiovasculaire (P.G. Steg / G. Ducroq), Vascular Inflammation and Thrombosis (M.C. Bouton / Y Boulaftali)
  • PARCC (Inserm U970) : Genetics and Gender in Cardiovascular Diseases (N. Bouatia-Naji), Pathophysiology of Heart Failure (J.S. Hulot), Inflammation and Multiorgan Dysfunction (C. Cochain), Cardiovascular Immunobiology (J.S. Silvestre, H. Ait-Oufella / Z. Mallat), Inflammation and Cardiac Diseases (D. Smadja)
  • Imagine : Congenital and developmental cardiovascular susceptibilities (S. Meilhac)
  • MASCOT : Biomarkers and Imaging (F. Azibani), Cardiovascular Immunobiology (B. Chousterman), Digital Biomarkers and AI  (E. Gayat)
  • OPTEN : Vascular Inflammation and Thrombosis (B. Ho-Tin-Noé / M. Mazighi)
  • CERILAC (Sciences humaines et sociales, UPCité) : Clinical Linguistics (S. Smadja)
  • Institut Pasteur : Inflammation and Tissue Repair (L. Peduto), CArdiovscular Immunometabolism (T. Wai)

By combining fundamental research, medical innovation, and the humanities and social sciences, CITY aims to transform the management of heart failure in young people. Its ambition is clear: to provide earlier, more personalized, and more humane solutions, and to help sustainably improve patients’ quality of life around the world.

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